https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Nanotechnology offers a range of options to lead to biology. Listed here I'll current illustrations wherever nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:
It had been only in the nineties though, when nanotechnology had Highly developed to some amount exactly where solitary molecules could be manipulated, that the 1st experimental gadgets started to look.
‘It had been merely a matter of finding up a ebook on cell biology and beginning to read through. I'd come from a environment of ultra-higher vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Deposition and atomic power microscopy of personal phthalocyanine polymers among nanofabricated electrodes
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Experimental stage diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is the fact these components jointly make up a living process. The secret of claimed lifestyle, I feel, lies within the interactions, the interaction of those molecules. The large dilemma in regards to the origin of lifetime is still unanswered. How did we ever evolve from basic molecules into the incredibly elaborate methods we see currently? We have no idea. I would like to operate on These types of huge, open up thoughts.’
Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
‘Yes, I recognize people have been astonished at time. At the conclusion of the nineties, After i was in my forties, I was Professor of Molecular Electronics and I have to confess that it experienced become a bit bored, I didn’t master Significantly anymore. The sphere went much more into the appliance facet, how you could integrate nanotubes into electronic circuits.
Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-generating process
‘The idea that There is certainly this type of matter like a starting, a huge bang, is by now a fascinating signpost to consider that there was a creator. But much more typically, and on The idea of pure rationality, I also get there in a Christian interpretation of fact. An atheistic worldview is often a naturalistic worldview: essentially, there are actually only atoms and natural forces that we can measure.
1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for any new Luttinger description of interacting electrons in nanotubes
2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-range conformational improvements in Mre11/DNA restore complexes; and 1st drive measurements on the DNA molecule in the nanopore
Lastly, I will briefly sketch a few of our Tips to check out the constructing of artificial cells, exclusively our first measures to https://www.ceesdekker.net ascertain artificial cell division.